Repurposing Platinum(IV) Prodrugs to Modulate Mitochondrial Metabolism

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVFirst ReactionsNEXTRepurposing Platinum(IV) Prodrugs to Modulate Mitochondrial MetabolismPlatinum(IV) prodrug overcomes acquired resistance to cisplatin in prostate cancer by inhibiting fatty acid oxidation.Emmanouil Zacharioudakis*Emmanouil ZacharioudakisDepartment of Biochemistry, Department of Medicine, Albert Einstein Cancer Center, Wilf Family Cardiovascular Research Institute and Institute for Aging Research, Albert Einstein College of Medicine, Bronx 10461, New York, United States*Email: [email protected]More by Emmanouil Zacharioudakishttps://orcid.org/0000-0003-2781-9553 and Raphaël Rodriguez*Raphaël RodriguezInstitut Curie, CNRS, INSERM, PSL Research University, Paris 75248, FranceEquipe Labellisée Ligue Contre le Cancer, Paris 75013, France*Email: [email protected]More by Raphaël Rodriguezhttps://orcid.org/0000-0001-7668-446XCite this: ACS Cent. Sci. 2023, XXXX, XXX, XXX-XXXPublication Date (Web):July 12, 2023Publication History Published online12 July 2023https://doi.org/10.1021/acscentsci.3c00654Published 2023 by American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (949 KB) Get e-AlertscloseSUBJECTS:Antineoplastic agents,Cancer,Cells,Genetics,Pharmaceuticals Get e-Alerts