化学
色谱法
黄曲霉毒素
溶剂
质谱法
乙腈
检出限
液态液体
萃取(化学)
分析化学(期刊)
欧洲联盟
液相色谱-质谱法
食品科学
经济政策
业务
有机化学
作者
Meng Sun,Dan Xu,Sicen Wang,Katsumi Uchiyama
标识
DOI:10.1021/acs.analchem.8b05344
摘要
A novel method was developed for determination of aflatoxin B1, B2, G1, and G2 (AFB1, AFB2, AFG1, and AFG2) in wheat using inkjet-based dispersive liquid-liquid microextraction (DLLME) coupled with ultrahigh-pressure liquid chromatography-tandem mass spectrometry. A drop-on-demand jetting device was used to form a cloudy solution in traditional DLLME by injecting extraction solvent (10 μL) as ultrafine droplets (∼20 μm diameter) at high frequency into sample solution. The method was validated using wheat as a representative matrix, which was pretreated with acetonitrile/water solution. Good linearity was observed over the studied range (0.06-6 μg/kg), and the limits of quantification (0.06-0.18 μg/kg) were below the maximum level established by the European Union for cereal. Satisfactory recoveries, ranging from 83.2% to 93.0% with relative standard deviations below 4.6%, were obtained for all compounds. The method, which is convenient and reliable and has low solvent consumption, represents a new direction for the development of traditional DLLME technology.
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