DNA折纸
纳米孔
乳状液
两亲性
生物物理学
微流控
纳米技术
DNA
材料科学
化学
有机化学
聚合物
共聚物
生物化学
纳米结构
生物
作者
Hao Huang,Tarun Belwal,Li Li,Yanqun Xu,Lina Zou,Xingyu Lin,Zisheng Luo
出处
期刊:Small
[Wiley]
日期:2021-10-04
卷期号:17 (45)
被引量:7
标识
DOI:10.1002/smll.202104831
摘要
Abstract Programmable engineered DNA origami provides infinite possibilities for customizing nanostructures with controllable precision and configurable functionality. Here, a strategy for fabricating an amphiphilic triangular DNA origami with a central nanopore that integrates phase‐stabilizing, porous‐gated, and affinity‐delivering effects is presented. By introducing the DNA origami as a single‐component surfactant, the water‐in‐oil‐in‐water (W/O/W) emulsion is effectively stabilized with decreased interfacial tension. Microscopic observation validates the attachment of the DNA origami onto the water‐in‐oil and oil‐in‐water interfaces. Furthermore, fluorescence studies and molecular docking simulations indicate the binding interactions of DNA origami with arbutin and coumaric acid at docking sites within central nanopores. These central nanopores are functionalized as molecular gates and affinity‐based scaffold for the zero‐order release of arbutin and coumaric acid at a constant rate regardless of concentration gradient throughout the whole releasing period. In vivo zebrafish results illustrate the advantages of this zero‐order release for anti‐melanogenesis therapy over direct exposure or Fickian diffusion. The DNA origami‐based W/O/W emulsion presents anti‐melanogenic effects against UV‐B exposure without cardiotoxicity or motor toxicity. These results demonstrate that this non‐toxic amphiphilic triangular DNA origami is capable of solely stabilizing the W/O/W emulsion as well as serving as nanopore gates and affinity‐based scaffold for constant release.
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