Zirconium Metal‐Organic Framework (UiO‐66) as a Robust Catalyst toward Solvent‐Free Synthesis of Remarkable Heterocyclic Rings

Abstract In the present paper, we report zirconium metal–organic framework (UiO‐66) as an efficient and robust catalyst for the straightforward synthesis of various nitrogen‐containing heterocyclic scaffolds, including imidazopyridine, pyridine and quinoxaline moieties. These compounds with potential drug value which exhibiting a broad spectrum biological and pharmacological activities were successfully accessed with MOF catalytic system under solvent‐free conditions. The main advantage of this protocol is reusability of catalyst, operational simplicity, mild reaction conditions and high‐yielding.