MA09.05 Tumoral ATF4-Mediated Fatty Acid Metabolism Disorder Fuels MDSC Reprogramming in LKB1-Mutant Lung Cancer

LKB1 mutations orchestrate an immune-desert microenvironment and elicit primary resistance to immunotherapy in lung cancer. However, the mechanisms by which LKB1-mutant cancer cells contribute to this immunosuppressive phenotype, as well as the crosstalk between tumor cells and the immune system, have yet to be fully elucidated.