癌症研究
突变体
免疫系统
医学
重编程
肿瘤微环境
表型
肺癌
免疫疗法
串扰
癌症
免疫学
细胞
生物
基因
遗传学
肿瘤科
内科学
物理
光学
作者
Zheng Guo,Y. Zhang,Xiaojing Bai
标识
DOI:10.1016/j.jtho.2023.09.175
摘要
LKB1 mutations orchestrate an immune-desert microenvironment and elicit primary resistance to immunotherapy in lung cancer. However, the mechanisms by which LKB1-mutant cancer cells contribute to this immunosuppressive phenotype, as well as the crosstalk between tumor cells and the immune system, have yet to be fully elucidated.
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