小RNA
非编码RNA
长非编码RNA
核糖核酸
中医药
计算生物学
生物信息学
生物
医学
基因
遗传学
病理
替代医学
作者
Guoqing Liu,Liqiang Tan,Xiaona Zhao,Minghui Wang,Zejin Zhang,Jing Zhang,Honggang Gao,Meifang Liu,Wei Qin
标识
DOI:10.3389/fphar.2023.1283494
摘要
Atherosclerosis is the leading cause of numerous cardiovascular diseases with a high mortality rate. Non-coding RNAs (ncRNAs), RNA molecules that do not encode proteins in human genome transcripts, are known to play crucial roles in various physiological and pathological processes. Recently, researches on the regulation of atherosclerosis by ncRNAs, mainly including microRNAs, long non-coding RNAs, and circular RNAs, have gradually become a hot topic. Traditional Chinese medicine has been proved to be effective in treating cardiovascular diseases in China for a long time, and its active monomers have been found to target a variety of atherosclerosis-related ncRNAs. These active monomers of traditional Chinese medicine hold great potential as drugs for the treatment of atherosclerosis. Here, we summarized current advancement of the molecular pathways by which ncRNAs regulate atherosclerosis and mainly highlighted the mechanisms of traditional Chinese medicine monomers in regulating atherosclerosis through targeting ncRNAs.
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