An Ultralong-Circulating Tantalum-Based Computed Tomography Contrast Agent for Vascular Imaging in Large Animals

-PEG NPs enabled high-resolution, whole-body vascular visualization, and supported accurate diagnosis and postoperative evaluation of vascular stenosis and thrombosis from single administration. The proposed ultra-long-term CTA strategy, leveraging non-iodinated high atomic number elements, offers a precise imaging approach with clinical translation potential for the pre- and post-treatment evaluation of vascular diseases.