染色质重塑
乙酰化
表观遗传学
组蛋白
骨重建
组蛋白修饰酶
组蛋白乙酰转移酶
染色质
细胞生物学
溴尿嘧啶
生物
计算生物学
化学
生物化学
遗传学
基因
作者
K. Gomathi,N. Akshaya,N. Srinaath,M. Rohini,N. Selvamurugan
标识
DOI:10.1016/j.ijbiomac.2020.12.173
摘要
Bone remodeling is a complex event that maintains bone homeostasis. The epigenetic mechanism of the regulation of bone remodeling has been a major research focus over the past decades. Histone acetylation is an influential post-translational modification in chromatin architecture. Acetylation affects chromatin structure by offering binding signals for reader proteins that harbor acetyl-lysine recognition domains. This review summarizes recent data of histone acetylation in bone remodeling. The crux of this review is the functional role of histone acetyltransferases, the key promoters of histone acetylation. The functional regulation of acetylation via noncoding RNAs in bone remodeling is also discussed. Understanding the principles governing histone acetylation in bone remodeling would lead to the development of better epigenetic therapies for bone diseases.
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