Pharmacokinetics and Tissue Distribution of HCPT Capsules in Mice

OBJECTIVE:To study the pharmacokinetics and tissue distribution of hydroxycamptothecine(HCPT) capsules in mice METHODS:The contents of HCPT in mouse plasma and tissues were determined by fluorescence spectrophotometry The pharmacokinetic parameters were measured RESULTS:The calibration curves of HCPT revealed linearity in the range 0 01～0 5μg/ml The plasma concentration-time curves of HCPT capsules conformed to two-conpartment model of pharmacokinetics The major pharmacokinetic parameters were:T1/2α 0 29h,T1/2β 1 64h,AUC0～24 14 73μg/ml and CL 12 53ml/h HCPT in gastrointestinal tissue AUCpoAUCiv,P0 05,but in whole body blood AUCpoAUCiv,P0 05 CONCLUSION:The oral administration of drug can increase the local-concentration in gastrointestinal tissue,which can raise the index of chemotherapy and reduce the systemic side-effects