已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Effect of Danshao Huaxian capsule on the expression of TGF-β_1 and Smad_(3/7) in the lung in rats with fibrosis pulmonary

作者
Qin Yang
出处
期刊:West China Journal of Pharmaceutical Sciences
摘要

OBJECTIVE To investigate the effect of Danshao Huaxian capsule(DSH) on TGF-β_1 and Smad_3/7 expression in rats with pulmonary fibrosis.METHODS Thirty Spague-Dawley rats were randomly divided into the control group,model group and test group.The model group and the test group were induced pulmonary fibrosis with endotracheal injection of bleomycin(5 mg·kg~-1),while the control group was given normal saline instead.From the second day of injection,the rats in the test group were administered intragastricly with DSH(0.8 g·kg~-1·d~-1),while the other rats were given normal saline instead.All rats were sacrificed at the twenty-eighth day,and the pathological changes in rats were detected.The expression of TGF-β_1 and Smad_3/7 were examined by immunohistochemical staining.RESULTS In model group,the lung coefficient,the Hyp content,expressions of TGF-β_1 and Smad_3 were significantly increased,while the expression of Smad_7 was decreased.Compared with model group,the lung coefficient were significantly decreased,pulmonary alveoli inflammation and pulmonary fibrosis were relieved,the Hyp content and expression of TGF-β_1 and Smad_3 were obviously decreased in the test group,but Smad_7 was significantly increased.CONCLUSION DSH has a good effect against experimental pulmonary fibrosis in rats.The mechanism may be associated with the influence of DSH on TGF-β_1/Smads signal transduction with down-regulating the expressions of TGF-β_1 and Smad_3 while up-regulating the expression of Smad_7.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
山野完成签到 ,获得积分10
刚刚
林兰特完成签到,获得积分10
刚刚
刚刚
ui24完成签到 ,获得积分10
2秒前
3秒前
Ghiocel完成签到,获得积分0
4秒前
yanglinhai完成签到 ,获得积分10
5秒前
稳重幻嫣发布了新的文献求助10
7秒前
9秒前
热情的衬衫完成签到,获得积分10
11秒前
初景应助有钱采纳,获得20
12秒前
小卢同学发布了新的文献求助10
15秒前
琦琦完成签到,获得积分10
16秒前
16秒前
在读芝士青年完成签到 ,获得积分10
17秒前
rachel关注了科研通微信公众号
18秒前
Becky完成签到,获得积分10
19秒前
ccc完成签到 ,获得积分10
20秒前
稳重幻嫣完成签到,获得积分20
21秒前
涂豆泥完成签到 ,获得积分10
21秒前
Jasper应助天真的道罡采纳,获得10
23秒前
25秒前
田様应助yym采纳,获得10
28秒前
29秒前
luang应助woaizuoshiyan采纳,获得10
31秒前
31秒前
zrssovereign完成签到 ,获得积分10
31秒前
molihuakai应助Jiong采纳,获得10
33秒前
MIJIALE完成签到 ,获得积分10
35秒前
江子川发布了新的文献求助10
36秒前
37秒前
37秒前
38秒前
39秒前
40秒前
40秒前
Nole应助晴天采纳,获得10
41秒前
杨y123发布了新的文献求助10
42秒前
43秒前
Jiong发布了新的文献求助10
44秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
China Pluperfect I: Epistemology of Past and Outside in Chinese Art 520
Matrix Methods in Data Mining and Pattern Recognition Second Edition 510
Cosmos as Art Object: Studies in Plato's Timaeus and Other Dialogues 500
What is the Future of Psychotherapy in Digital Age? Technology, AI Bots, and Psychotherapy after Covid 444
Management and the Arts 310
Teaching Social and Emotional Learning in Physical Education 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7633366
求助须知:如何正确求助?哪些是违规求助? 9207538
关于积分的说明 19747722
捐赠科研通 7202171
什么是DOI,文献DOI怎么找? 3274916
关于科研通互助平台的介绍 2436843
邀请新用户注册赠送积分活动 2271761