三萜
齿叶乳香树
化学
立体化学
酶
生物化学
脂氧合酶
花生四烯酸5-脂氧合酶
基质(水族馆)
萜烯
戒指(化学)
生物
花生四烯酸
有机化学
医学
病理
替代医学
生态学
作者
H. Safayhi,E.‐R. Sailer,H. P. T. Ammon
出处
期刊:Phytomedicine
[Elsevier]
日期:1996-05-01
卷期号:3 (1): 71-72
被引量:32
标识
DOI:10.1016/s0944-7113(96)80013-4
摘要
Acetyl-11-keto-β-boswellic acid (AKAB) from Boswellia serrata and B. carterii acts directly on purified 5-lipoxygenase of human blood leukocytes at a selective site for pentacyclic triterpenes that is different from the arachidonate substrate binding site. The pentacyclic triterpene ring is crucial for binding to the enzyme, whereas functional groups (11-keto function in addition to a hydrophilic group on C 4 of ring A) are essential for the 5-lipoxygenase activity.
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