Wnt信号通路
Hes3信号轴
信号转导
癌变
生物
刺猬
Notch信号通路
细胞信号
细胞生物学
癌症研究
癌症
骨形态发生蛋白
遗传学
基因
作者
William Wu,Chi H. Cho,Chung W. Lee,Daiming Fan,Kaichun Wu,Jun Yu,Joseph J.Y. Sung
出处
期刊:Cancer Letters
[Elsevier]
日期:2010-09-01
卷期号:295 (2): 144-153
被引量:146
标识
DOI:10.1016/j.canlet.2010.04.025
摘要
The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation of intracellular signaling pathways represents a common pathogenic mechanism and may be amenable to drug targeting. Multiple well-established oncogenic pathways, such as those mediated by cell cycle regulators, nuclear factor-kappaB, cyclooxygenase-2 and epidermal growth factor receptor are implicated in gastric carcinogenesis. Emerging evidence also underscores the importance of signaling pathways involved in the developmental process, including transforming growth factor-beta/bone morphogenetic protein signaling, Wnt/beta-catenin signaling, Hedgehog signaling and Notch signaling. Understanding their biological significance will provide a rational basis for drug development. Their relative importance and cross-talk in gastric carcinogenesis, however, are still not completely understood and warrant further investigation.
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