线粒体
细胞凋亡
荧光
极性(国际关系)
生物物理学
跟踪(教育)
细胞生物学
化学
生物
细胞
光学
物理
生物化学
心理学
教育学
作者
Xinru Wang,Qi Chen,Jiale Ou,Yinliang Huang,Congchun Wang,Yue-an Chen,Jilou Qin,Man Chen,Yan Feng,Guoyong Xu,Xiangming Meng
标识
DOI:10.1016/j.snb.2021.130953
摘要
Mitochondria polarity and morphology can work as the important features for tracking the mitochondria-related apoptosis. Herein, we designed a multifunctional two-photon fluorescent probe Mito-PF with mitochondria-anchoring ability, which can not only quantitatively monitor the fluctuation of polarity using the dual-channel imaging mode, but also directly visualize the changes of mitochondrial morphology. Benefits from its multiple performance, real-time and accurate monitoring of mitochondria-related apoptosis can be achieved through ratio two-photon imaging of the mitochondria-related parameters (polarity and morphology). In addition, we successfully utilized Mito-PF to assess drug bpV(phen) and presented that bpV(phen) has a remarkable ability to induce mitochondria-related apoptosis.
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