生物
疾病
微生物群
炎症
免疫学
生物信息学
病理
医学
作者
Johan Björkegren,Aldons J. Lusis
出处
期刊:Cell
[Elsevier]
日期:2022-05-01
卷期号:185 (10): 1630-1645
被引量:347
标识
DOI:10.1016/j.cell.2022.04.004
摘要
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
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