诱导多能干细胞
烟雾病
机制(生物学)
神经科学
疾病
胚胎干细胞
医学
生物
生物信息学
病理
遗传学
外科
基因
哲学
认识论
作者
Yu Xue,Qian Zhang,Linjian Wang,Wen‐Jun Tu,Jizong Zhao
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2023-08-01
卷期号:18 (6): 733-739
被引量:1
标识
DOI:10.2174/1574888x17666220607121027
摘要
Moyamoya disease (MMD) is a chronic steno-occlusion cerebrovascular disease accompanied by the formation of the abnormal vascular network at the base of the brain. The etiology of MMD is not fully clarified. Lack of pathological specimens hinders the research progress. Induced pluripotent stem cells (iPSC) derived from patients with outstanding differentiation potential and infinite proliferation ability could conquer the problem of insufficient samples. The technology of iPSC holds the promise of clarifying the underlying molecular mechanism in the development of MMD. In this review, we summarized the latest progress and difficulties in the research of mechanism and detailed the application of iPSC in MMD, aiming to provide an outlook of iPSC in molecular mechanism and novel therapies of MMD.
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