神经发生
选择性拼接
RNA结合蛋白
生物
RNA剪接
神经科学
核糖核酸
长非编码RNA
基因亚型
细胞生物学
遗传学
基因
作者
Enrique Lara‐Pezzi,Manuel Desco,Alberto Gatto,Marı́a Victoria Gómez-Gaviro
标识
DOI:10.1177/1073858416678604
摘要
The complexity of the mammalian brain requires highly specialized protein function and diversity. As neurons differentiate and the neuronal circuitry is established, several mRNAs undergo alternative splicing and other posttranscriptional changes that expand the variety of protein isoforms produced. Recent advances are beginning to shed light on the molecular mechanisms that regulate isoform switching during neurogenesis and the role played by specific RNA binding proteins in this process. Neurogenesis and neuronal wiring were recently shown to also be regulated by RNA degradation through nonsense-mediated decay. An additional layer of regulatory complexity in these biological processes is the interplay between alternative splicing and long noncoding RNAs. Dysregulation of posttranscriptional regulation results in defective neuronal differentiation and/or synaptic connections that lead to neurodevelopmental and psychiatric disorders.
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