克隆形成试验
胰腺癌
细胞凋亡
癌症研究
放射治疗
膜联蛋白
体外
聚ADP核糖聚合酶
癌症
医学
癌细胞
化疗
肿瘤科
内科学
化学
聚合酶
生物化学
酶
作者
Yunhuiv Jo,Geon Oh,Yongha Gi,Heehun Sung,Eun Bin Joo,Suk Lee,Myonggeun Yoon
标识
DOI:10.1080/09553002.2020.1838658
摘要
Purpose Tumor treating fields (TTF) therapy is a noninvasive method that uses alternating electric fields to treat various types of cancer. This study demonstrates the combined effect of TTF and radiotherapy (RT) in vitro on pancreatic cancer, which is known to be difficult to treat.Materials and methods In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of TTF and RT was evaluated by measuring cell counts, markers of apoptosis, and clonogenic cell survival. The synergy effects were verified using the Valeriote and Carpentier equations.Results TTF and RT inhibited cancer cell growth more effectively than did monotherapy with TTF or RT. The combined treatment also enhanced apoptosis more than monotherapy, as shown by assays for cleaved poly (ADP-ribose) polymerase (PARP) and annexin V. In addition, on the survival curve, this treatment method has been shown to work synergistically.Conclusion These results suggest that combined treatment with TTF and RT may be a good alternative treatment for patients with pancreatic cancer.
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