量子点
渗透(战争)
人体皮肤
材料科学
皮肤屏障
功能(生物学)
纳米技术
医学
皮肤病科
生物
进化生物学
运筹学
工程类
遗传学
作者
Supriya Ravichandran,Luke J. Mortensen,Lisa A. DeLouise
出处
期刊:Nanotoxicology
[Taylor & Francis]
日期:2010-12-10
卷期号:5 (4): 675-686
被引量:22
标识
DOI:10.3109/17435390.2010.537381
摘要
In this study, we utilize in vivo human skin and a viable ex-vivo human skin model to investigate the effect of a commercial depilatory agent on barrier function. Tape stripping was used as a positive control. The magnitude of skin barrier was quantified by measuring transepidermal water loss values on in vivo human skin and transepithelial electrical resistance measurements and tissue histology on ex vivo skin. The susceptibility to carboxylated quantum dot penetration through ex vivo skin was investigated using fluorescent microcopy analysis of microtomed skin sections and flow cytometry to quantify quantum dot association with live epidermal cells. Results show that depilatory treatment modifies the outside-in barrier sufficiently to allow quantum dots to penetrate the stratum corneum but to a lesser extent than tape stripping. The implications of these finding are discussed.
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