孟德尔随机化
疾病
牙周病
医学
观察研究
阿尔茨海默病
临床试验
因果关系(物理学)
内科学
生物
遗传学
基因
遗传变异
基因型
量子力学
物理
作者
Chaoqun Hu,Hui Li,Liping Huang,Liping Huang,Rui Wang,Zeyu Wang,Rui Ma,Bei-Hung Chang,Shiting Li,Shiting Li,Hongcai Li,Guangwen Li,Guangwen Li,Guangwen Li
摘要
Abstract Background Evidence from observational studies and clinical trials suggests an association between periodontal disease and Alzheimer's disease (AD). However, the causal relationship between periodontal disease and AD remains to be determined. Methods We obtained periodontal disease data from the FinnGen database and two sets of AD data from the IEU consortium and PGC databases. Subsequently, we conducted a two‐sample Mendelian randomization (MR) analysis to investigate the causal relationship between periodontal disease and AD. Results The results of the random‐effects IVW analysis revealed no evidence of a genetic causal relationship between periodontal disease and AD, regardless of whether the AD data from the IEU consortium or the AD data from the PGC database were utilized. No heterogeneity, multiple effects of levels, or outliers were observed in this study. Conclusions Our findings indicate that there is no causal relationship between periodontal disease and AD at the genetic level.
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