Surgical treatment and prognosis of colorectal liver metastases

Objective To evaluate the curative effect and prognosis of hepatic resection for colorectal liver metastases(CLM).Methods Thirty-five cases of CLM were treated with hepatectomy from Jan.1999 to Feb.2006.Clinical and follow-up data of these cases were analyzed retrospectively.The cumulative survival rate was analyzed by Kaplane-Meier method.Multiple factor analysis was introduced by Cox's proportional hazard model.Results The survival rates of overall 1-,3-,and 5-year were 93.5%,68.5% and 39.9%,respectively.According to univariate analysis,the survival rate was affected by tumor size,surgical margin,lymphatic metastasis,type of liver metastases,metastatic carcinoma differentiation significantly(P0.05).Multiple factor analysis revealed that tumor size(P=0.012),incisal margin(P=0.027)were independent factors on survival rate.Conclusions Hepatectomy can prolong survival time of patients with CLM.Either tumor size of 5cm or negative incisal margin predicts a better survival.