苏氨酸
丝氨酸
糖基化
生物化学
N-乙酰氨基葡萄糖
细胞生物学
细胞质
乙酰氨基葡萄糖
化学
磷酸化
生物
酶
作者
Gerald W. Hart,Michael P. Housley,Chad Slawson
出处
期刊:Nature
[Springer Nature]
日期:2007-04-01
卷期号:446 (7139): 1017-1022
被引量:1254
摘要
All animals and plants dynamically attach and remove O-linked β-N-acetylglucosamine (O-GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O-GlcNAc cycling, which is tightly regulated by the concerted actions of two highly conserved enzymes, serves as a nutrient and stress sensor. On some proteins, O-GlcNAc competes directly with phosphate for serine/threonine residues. Glycosylation with O-GlcNAc modulates signalling, and influences protein expression, degradation and trafficking. Emerging data indicate that O-GlcNAc glycosylation has a role in the aetiology of diabetes and neurodegeneration.
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