艾塞那肽
医学
餐后
二甲双胍
内科学
内分泌学
2型糖尿病
胰岛素
甘精胰岛素
肠促胰岛素
胃排空
糖尿病
2型糖尿病
低血糖
血糖性
减肥
耐受性
药理学
不利影响
肥胖
胃
作者
Raffaella Gentilella,Cristina Bianchi,Andrea Rossi,Carlo Maria Rotella
标识
DOI:10.1111/j.1463-1326.2008.01018.x
摘要
BACKGROUND: Exenatide is an incretin mimetic that activates glucagon-like-peptide-1 receptors. It blunts the postprandial rise of plasma glucose by increasing glucose-dependent insulin secretion, suppressing inappropriately high glucagon secretion and delaying gastric emptying. METHODS: In seven clinical trials performed in 2845 adult patients with type 2 diabetes mellitus who were inadequately controlled by a sulphonylurea and/or metformin (glycosylated haemoglobin, HbA1c
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