医学
限制性肺病
间质性肺病
肺
儿科
内科学
肺移植
呼吸窘迫
羟基氯喹
外科
作者
Elodie Nattes,Stéphanie Lejeune,Ania Carsin,Raphael Borie,Isabelle Gibertini,Juan E. Balinotti,Nadia Nathan,Sylvain Marchand-Adam,Caroline Thumerelle,Brigitte Fauroux,Emmanuelle Bosdure,Véronique Houdouin,Céline Delestrain,Malek Louha,Remy Couderc,Alix de Becdelièvre,Pascale Fanen,Benoît Funalot,Bruno Crestani,Antoine Deschildre,Jean-Christophe Dubus,Ralph Epaud
标识
DOI:10.1016/j.rmed.2017.05.014
摘要
We retrospectively studied the clinical presentation, treatment modalities and outcome in 16 patients with heterozygous NKX2-1 mutation associated with chronic lung disease. Twelve different NKX2-1 mutations, including 4 novel mutations, were identified in the 16 patients. Nine patients presented with brain-lung-thyroid syndrome, 3 had neurological and lung symptoms and 4 had only pulmonary symptoms. Ten patients had neonatal respiratory distress, and 6 of them developed infiltrative lung disease (ILD). The other patients were diagnosed with ILD in childhood (n = 3) or in adulthood (n = 3). The median age at diagnosis was 36 months (IQ 3.5-95). Patient testing included HRCT (n = 13), BALF analysis (n = 6), lung biopsies (n = 3) and lung function tests (n = 6). Six patients required supplemental oxygen support with a median duration of 18 months (IQ 2.5-29). All symptomatic ILD patients (n = 12) benefited from a treatment consisting of steroids, azithromycin (n = 9), and/or hydroxychloroquine (n = 4). The median follow-up was 36 months (IQ 24-71.5). One patient died of respiratory failure at 18 months and another is waiting for lung transplantation. In summary, the initial diagnosis was based on clinical presentation and radiological features, but the presentation was heterogeneous. Definitive diagnosis required genetic analysis, which should be performed, even in absence of neurological or thyroid symptoms.
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