试验药物
医学
病毒学
疾病
乙型肝炎病毒
药物开发
临床试验
重症监护医学
药品
病毒
丙型肝炎病毒
病毒性肝炎
肝细胞癌
丁型肝炎病毒
丁型肝炎
内科学
药理学
乙型肝炎表面抗原
作者
Bilal Asif,Christopher Koh
标识
DOI:10.1080/13543784.2021.1977795
摘要
Chronic Hepatitis D virus (HDV) infection is a global disease leading to rapidly progressive liver disease with increased liver-related mortality and hepatocellular carcinoma. Therapies are minimally effective; however, an increased understanding of the HDV lifecycle has provided new potential drug targets. Thus, there is a growing number of investigational therapeutics under exploration for HDV with the potential for successful viral eradication.This review discusses the clinical impact of HDV infection and offers an in-depth look at the HDV life cycle. The authors examine current and new drug targets and the investigational therapies in clinical trials. The search strategy was based on PubMed database and clinicaltrials.gov which highlight the most up-to-date aspects of investigational therapies for chronic HDV infection.
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