矿化(土壤科学)
牛血清白蛋白
材料科学
电解质
涂层
化学工程
电化学
微观结构
沉积(地质)
粘附
化学
复合材料
电极
色谱法
有机化学
生物
沉积物
工程类
物理化学
古生物学
氮气
作者
Jingjing Zhuang,Jun Lin,Juan Li,Huiming Wang,Kui Cheng,Wenjian Weng
标识
DOI:10.1016/j.msec.2016.04.088
摘要
In this work, mineralized collagen coatings with different loading quantity of bovine serum albumin (BSA) were prepared via in situ electrochemical deposition on titanium substrate. The microstructure and BSA loading quantity of the coatings could be controlled by the electrochemical deposition parameters, such as deposition potential, BSA concentration and its adding sequence in the electrolyte. The BSA loading quantity in the coatings was obtained in the range of 0.0170-0.173mg/cm(2), enhancing the cell adhesion and proliferation of the coatings with the simultaneous release. The distinct release behaviors of BSA were attributed to their gradient distribution with different mineralization degrees, which could be adjusted by the deposition process. These results suggest that in situ electrochemical deposition is a promising way to incorporate functional molecules into the mineralized collagen coatings and the mineralized BSA/collagen coatings are highly promising for improving the rhBMP-2 loading capability (1.8-fold).
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