Connective Tissue Growth Factor,a New Target for Anti-Liver Fibrosis

Connective tissue growth factor(CTGF) and transform growth factor-β(TGF-β) are highly expressed in many fibrotic tissues and organs.It is thought that they are main cytokines promoting fibrogenesis.As the downstream effect media of TGF-β,CTGF mediates its role of promoting fibrosis,but it is not correlated with its role of anti-inflammation and regulation of immunity.For this reason CTGF maybe become a better target for anti-liver fibrosis.