Treatment of Aortic and Cardiac Injury Following Sepsis by Curcumin Green‐Formulated Silver Nanoparticles

ABSTRACT The main secondary metabolite of turmeric is a polyphenol molecule called curcumin. According to Chinese traditional medicine, the chemical offers a number of advantages. Nevertheless, no research has examined the possible advantages of its nanoparticles in reducing sepsis‐induced cardiac and aortic damage thus far. Therefore, the purpose of this work was to examine how oxidative stress markers and nitric oxide (NO) are affected by silver nanoparticles green‐formulated by curcumin in sepsis‐induced aortic and cardiac damage. This study characterizes and synthesizes silver nanoparticles using green formulation techniques. Several spectroscopic techniques were used to analyze the silver nanoparticles, and their ability to cure sepsis‐induced cardiac and aortic damage was also investigated. Adult male Wistar rats were classified into four groups for the in vivo design: control, lipopolysaccharide, and silver nanoparticles (50 and 200 μg/kg, oral). For 14 days, lipopolysaccharide (LPS) was injected every day. Silver nanoparticle therapy began 3 days before the delivery of LPS and continued during the administration of LPS. Antioxidant enzyme, thiols, NO, and malondialdehyde (MDA) levels were assessed after the research. The findings imply that silver nanoparticles can prevent cardiovascular damage caused by LPS by reducing NO generation and enhancing redox hemostasis. Our results demonstrated that the LPS group's levels of superoxide dismutase (SOD), thiols, and catalase (CAT) were significantly reduced; these levels were subsequently restored by silver nanoparticles. Silver nanoparticles also reduced NO and MDA levels in the cardiac and aortic tissues of LPS‐injected rats. The new nanoparticles might be utilized to repair human cardiac and aortic damage caused by sepsis following clinical trial research.