DU145型
药效团
化学
类有机物
前列腺癌
结直肠癌
前列腺
癌症
Hsp90抑制剂
热休克蛋白90
癌症研究
内科学
生物化学
热休克蛋白
医学
细胞生物学
生物
基因
LNCaP公司
作者
Di-Wei Tang,I‐Chung Chen,Po-Yu Chou,Mei-Jung Lai,Zhengyang Liu,Kelvin K. Tsai,Li‐Hsin Cheng,Jian-Xun Zhao,Er-Chieh Cho,Hung-Hsuan Chang,Tony Eight Lin,Kai‐Cheng Hsu,Mei-Chuan Chen,Jing‐Ping Liou
标识
DOI：10.1016/j.ejmech.2024.116801
摘要
The rational installation of pharmacophores targeting HSP90 and LSD1 axes has achieved significant anti-cancer capacity in prostate and colorectal cancer. Among the series of hybrids, inhibitor 6 exhibited remarkable anti-proliferative activity against prostate cancer cell lines PC-3 and DU145, with GI
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