THE APPLICATIONOF RESPONSE SURFACE METHODOLOGY IN OPTIMIZATION OF MICROBIAL MEDIA

Statistical methods and optimization techniques have been widely used to determine micro-bial media. According to the principle of the response surface analysis, the advantages of response sur-face methodology (RSM), the method of experimental design and data handling are discussed in thispaper. The concrete application of RSM was illuminated through the decision of medium ingredients forproducing cellulase by Trichoderma reesei RutC- 30.