Comparison of Muscular Relaxation Effects of Cisatracurium by Different Intravenous Methods in Old Patients

Objective To study the effects of different administration of cisatracurium on neuromuscular blockade in old patients.Methods Sixty patients(ASA) aged 65～87 undergoing general anesthesia were randomly divided into three groups(n=20).Patients were performed with 0.9% sodium chloride injection by 0.15 mg/kg cisatracurium after 3 min by intravenous injection(group A) or a priming dose of 0.01 mg/kg cisatracurium followed by 0.14 mg/kg 3 min later by intravenous injection(group B and C),and then patients received intermittent dose of 0.03 mg/kg cisatracurium when needed or received 3 μg/kg.min cisatracurium.Neuromuscular blocking effects were monitored with an accelerometer.Results The onset time in group B and C were shorter than those in group A(P0.05).The clinical duration in group A and B was longer than those in group C(P0.05). There was no significant difference on recovery index among three groups.Conclusion Old patients injected by intravenous a drop dose priming cisatracurium can significantly shorten the onset time,and the continuing infusion can implement rapid onset and fast recovery.