污染
致癌物
空气污染
肺
环境科学
肺癌
环境化学
毒理
化学
医学
病理
生物
内科学
生态学
生物化学
作者
M S F Reymao,Patrı́cia Maluf Cury,A.J.F.C. Lichtenfels,Miriam Lemos,Cláudia Naves Battlehner,Gleice M.S. Conceição,Vera Luíza Capelozzi,G. S. Montes,Mauricio Francisco Caliri Júnior,M. A. Martins,György Böhm,Paulo Hilário Nascimento Saldiva
标识
DOI:10.1006/enrs.1997.3740
摘要
This paper investigates the association between air pollution and lung neoplasia in an animal model. The experimental exposures were done in two locations with different air pollution profiles: a polluted area (downtown São Paulo) and a “clean” environment (Atibaia). Swiss mice were employed and urethane (3 g/kg) was used as carcinogenic substance. Two experiments were performed: Experiment I was designed to verify whether air pollution acts as initiator and/or promoter of lung cancer, using 300 mice; Experiment II employed 250 animals and aimed to verify if the effects of air pollution on the development of lung tumors was dose dependent. A significant effect of air pollution in augmenting lung carcinogenecity induced by urethane was observed. This effect was shown to be dose-dependent and reproducible on two different occasions. In addition, morphometric studies revealed that pollution may influence tumor phenotype. These results support the hypothesis that air pollution plays a significant role in the development of lung tumors.
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