可药性
医学
三阴性乳腺癌
脑转移
临床试验
乳腺癌
药品
靶向治疗
药物发现
药物输送
癌症
转移
肿瘤科
生物信息学
内科学
药理学
纳米技术
生物
材料科学
基因
生物化学
作者
Maryam Nakhjavani,Rasika M. Samarasinghe,Sarah Shigdar
标识
DOI:10.1016/j.drudis.2022.01.010
摘要
The key challenges with the treatment of triple-negative breast cancer brain metastasis (TNBC-BM) are the lack of any targeted therapy and difficulties associated with drug delivery to the brain. These add to the high toxicity profile of existing treatments and the poor outcomes for patient. In this review, we introduce current drugs based on their molecular targets and look to improve brain drug delivery using more efficient and promising drug delivery systems. We describe ongoing clinical trials on druggable targets in TNBC-BM for a more targeted treatment and introduce the obstacles hindering drug delivery to the brain, bringing strategies and advancing knowledge for future steps in the treatment of patients with TNBC-BM.
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