The Development of a Physiologically Based Pharmacokinetic (PBPK) Model ofAndrographolide in Mice and Scaling it up to Rats, Dogs, and Humans

The PBPK model of andrographolide in animals and humans was successfully constructed. Once additional data is available, the model would be needed to recalibrate to gain an understanding of a dose-response relationship and optimization of dosage regimens of andrographolide.