化学
硒
区域选择性
芳基
催化作用
电泳剂
催化循环
药物化学
硼酸
亲电加成
苯
有机化学
组合化学
烷基
作者
Jin-Rong Lai,Fu-Dan Yin,Qingsong Guo,Fei Yuan,Bei-Fang Nian,Ming Zhang,Zhi-Bang Wu,Hongbin Zhang,E Tang
摘要
An Ag-catalysed three-component reaction of alkynyl aryl ketones bearing an ortho-methoxy group, element selenium, and arylboronic acid, providing a facile route to selenofunctionalized chromone products has been developed. This protocol features high efficiency and high regioselectivity, and the use of selenium powder as the selenium source. Mechanistic experiments indicated that the combined oxidative effect of (bis(trifluoroacetoxy)iodo)benzene and oxygen in the air pushes the catalytic redox cycle of the Ag catalyst and the phenylselenium trifluoroacetate formed in situ is the key intermediate of the PIFA-mediated 6-endo-electrophilic cyclization and selenofunctionalization reaction of alkynyl aryl ketones.
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