A green approach to the synthesis of novel phytosphingolipidyl β-cyclodextrin designed to interact with membranes

This work reports the synthesis of a new family of mono-substituted amphiphilic cyclodextrins using a green methodology. Reactions using greener and safer catalysts with more environmentally friendly purification solvents were performed. Four unreported mono-substituted cyclodextrins bearing a phytosphingolipidyl chain and a fatty acid chain (C 10 , C 12 , C 14 and C 18 ) were successfully obtained with a promising yield.