纳米载体
乙二醇
蛋白质吸附
聚合物
PEG比率
化学
吸附
共聚物
化学工程
日冕(行星地质学)
生物物理学
高分子化学
材料科学
药物输送
有机化学
工程类
经济
物理
天体生物学
生物
财务
维纳斯
作者
Johanna Simon,Thomas Wolf,Katja Klein,Katharina Landfester,Volker Mailänder
标识
DOI:10.1002/anie.201800272
摘要
Increasing the plasma half-life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half-life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester-coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composition of the protein corona and the cell interaction. Upon a significant change in hydrophilicity, the overall amount of blood proteins adsorbed on the nanocarrier remained unchanged, while the protein composition varied. This result underlines the importance of the protein type for the protein corona and cellular uptake.
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