WCN23-0949 PGC1α MODULATES MITOCHONDRIAL HOMEOSTASIS IN TUBULAR CELLS OF DIABETIC KIDNEY DISEASE

Tubular injury and dysregulated mitochondrial dynamics play pivotal roles in the pathogenesis of diabetic kidney disease (DKD). However, the potential mechanism by which mitochondrial dysfunction-initiated tubulopathy triggers intrarenal signaling and mediates DKD progression remains elusive. Our current study aims to investigate the effect of PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1 alpha)-modulated mitochondrial homeostasis on renal tubular cells of DKD and to explore the underlying mechanisms.