Amphiregulin in Cancer: New Insights for Translational Medicine

Although there is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focuses on its cell-autonomous functions in epithelial malignancies. Recent studies revealed that AREG is also present in the tumor microenvironment (TME) and contributes to therapeutic resistance. We discuss emerging concepts of AREG tumor biology and highlight their implications for translational medicine.