Study on Multiple Sclerosis Treatment by Intrathecal Injection of Methylprednisolone

Objective:To evaluate the effect of intrathecal injection of methylprednisolone in patients of acute multiple sclerosis(MS).Methods:Seventy cases were divided into intrathecal methylprednisolone group(n=32) and methylprednisolone impact group(n=38).The reduction of Kurtzke expanded disability status scale(EDSS) and the rate of side effects after treatment were evaluated.The average total cost of hospitalization,the average cost per hospital day and the proportional contribution of medications were analysed with the software of SPSS13.0.Results:The average improvement of EDSS after 5 days treatment was significantly obvious in intrathecal methylprednisolone group compared with that of methylprednisolone impact group(P 0.05),but no difference after 15 days treatment(P 0.05).There were significantly lower values in the average total cost of hospitalization,the average cost per hospital day,average hospitalization day and the proportional contribution of medications in intrathecal methylprednisolone group than those of methylprednisolone impact group(P 0.05).Conclusion:The intrathecal methylprednisolone therapy showed a fast improvement of EDSS scale,reduced average hospitalization day and lower average total cost of hospitalization in patients with multiple sclerosis.