444 It has been suggested that Eleutherococcus senticosus (ES), also known as Siberian ginseng or ciwuija, has the ability to increase fat utilization in man. This implies a sparing effect of muscle glycogen stores, and possible enhancement in performance during prolonged work. Recent well-designed studies have shown no effect on short duration work; however, there are no studies investigating long duration work. Therefore, it was the purpose of this study to examine the physiological responses to supplementation of ES on endurance cyclists. Using a randomized, double-blind crossover design, 10 highly-trained men (28 ±1 yr, VO2max 56.9 ±1.8 ml·kg−1·min−1) cycled for 120 min at ∼60% VO2max followed by a simulated 10-km time trial. Diet was controlled and ES (1200-mg·day−1) or a placebo (P) were administered for seven days prior to each of the two trials. Oxygen consumption, respiratory exchange ratio, and heart rate were recorded every 30-min and rating of perceived exertion, plasma lactate, and plasma glucose were recorded every 20 min during the 120 min of steady state. 10-km performance time was recorded for the time trial. There were no significant differences (P>0.05) between the ES and P groups at any steady-state measurement point or during the cycling time trial (ES, 18.41 ±0.49; P, 18.21 ±0.57 min). These results suggest that ES supplementation does not alter steady-state substrate utilization or 10-km cycling performance time. Supplement provided by PacificHealth Laboratories, Inc.