Preferential Attack of Mitochondrial DNA by Aflatoxin B 1 During Hepatocarcinogenesis

Administration of the hepatic carcinogen aflatoxin B 1 to experimental animals results in covalent binding to liver mitochondrial DNA at concentrations three to four times higher than nuclear DNA. The concentration of carcinogen adducts in mitochondrial DNA remains unchanged even after 24 hours, possible because of lack of excision repair. Similarly, mitochondrial transcription and translation remain inhibited up to 24 hours suggesting long-term effects of aflatoxin B 1 on the mitochondrial genetic system.