MASLD in the cardiovascular–kidney–metabolic health framework: what does it add to the table?

In 2023, the American Heart Association introduced the Cardiovascular-Kidney-Metabolic (CKM) health framework, a new paradigm for integrated cardiovascular disease (CVD) prevention and management across the cardiovascular, kidney, and metabolic axes. 1 CKM syndrome is conceptualized as a multisystem disorder in which excess or dysfunctional adiposity, insulin resistance, hypertension, dyslipidemia, diabetes, and impaired kidney function interact to drive the development and progression of cardiovascular and kidney disease.The