Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing

PROM1 and THY1 were critical diagnostic biomarkers for renal fibrosis in DKD, with PROM1 promoting kidney fibrosis and THY1 providing protective effects. The FibrosisScore model demonstrated robust predictive performance, and molecular docking revealed potential therapeutic modulators for these targets.