Stereoselective Construction of 5-6-5 Aza-Tricyclic Scaffolds via Catalytic Asymmetric Aza-Piancatelli/Diels-Alder Reactions

A chiral Brønsted acid catalyzed asymmetric cascade aza-Piancatelli rearrangement/intramolecular Diels-Alder reaction has been developed. This method enables the atom- and step-efficient synthesis of chiral aza-[5,6,5]-tricyclic derivatives with multiple contiguous stereocenters...