The purpose of the study was to evaluate the effect of manipulation of wrist technique and Cyriax physiotherapy training in reducing pain and improving grip strength in lateral epicondylitis. A total of 30 patients (male =16; female=14) were selected as subjects and they were further divided into 2 groups. Each group comprising of 15 subjects (male=8; female=7). Results of this study suggest that there was an improvement in the mean values of Numeric Pain Rating Scale and Grip Strength after treatment in both groups. But the improvement was statistically more significant in wrist manipulation group than the Cyriax physiotherapy training receiving group. It was concluded that the patients of lateral epicondylitis procured more substantial benefits from wrist manipulation as compared to Cyriax physiotherapy after three weeks.