材料科学
介孔二氧化硅
药物输送
介孔有机硅
纳米材料
生物相容性
石墨烯
介孔材料
纳米-
纳米技术
纳米颗粒
复合材料
催化作用
化学
有机化学
冶金
作者
Xing Ma,Huanhuan Feng,Chunyan Liang,Xiaojia Liu,Fanyu Zeng,Yong Wang
标识
DOI:10.1016/j.jmst.2017.06.007
摘要
Mesoporous silica has been widely explored for biomedical applications due to its unique structure and good biocompatibility. In particular it exhibits superior properties as micro/nano-carriers in the biomedical field. We explore their potentials in controlled drug/gene co-delivery and photodynamic therapy for cancer treatment both in vitro and in vivo. By incorporating mesoporous silica nanoparticles (MSNP) with two-dimensional nanomaterial, graphene oxide nano-sheet, we utilize MSNP in cellular bio-imaging with squaraine dye. Meanwhile, through delicate combination between mesoporous silica micro/nano carriers with catalytic/bio-catalytic reactions, we manage to achieve self-propelled micro/nano-motors based on mesoporous silica that are capable of transporting cargos in an active manner. Especially, enzyme powered mesoporous silica motors can be powered by physiologically available fuels such as glucose and urea, which are advantageous for future biomedical use. Motion control on both velocity and movement direction provides a powerful tool for targeted drug delivery. Therefore, such mesoporous silica based active carriers pave way to the solution of targeted drug delivery for cancer treatment in future nano-medicine field.
科研通智能强力驱动
Strongly Powered by AbleSci AI