化学
水溶液
肿胀 的
溶解度
溶解
肠衣
分散性
纳米颗粒
邻苯二甲酸盐
溶剂
色谱法
核化学
化学工程
剂型
高分子化学
有机化学
工程类
作者
Il Hyuk Kim,Jung Hwan Park,In Woo Cheong,Jung Hyun Kim
标识
DOI:10.1016/s0168-3659(03)00089-0
摘要
Organic solvent-based enteric coating technology using hydroxypropyl methyl cellulose phthalate (HPMCP) has been developed for many years due to low water solubility of HPMCP. In this work, aqueous HPMCP nanoparticles (HPMCP-NPs) were prepared by neutralization emulsification method using HPMCP powder and ammonium hydroxide (NH(4)OH) in the absence of any organic solvent and emulsifier. Tablets for enteric use were coated with HPMCP-NP dispersions having different degree of neutralization that was manipulated by ion-exchange process. Disintegration and dissolution behavior of coated tablets were investigated using UV-visible spectrophotometer based on USP method (pH 1.2 and at 37 degrees C) and simulated intestinal fluid (pH 6.8 and at 37 degrees C for 60 min), respectively. The ion-exchange process, which was directly achieved by the protonation of dissociated carboxylic acid group of the aqueous HPMCP-NPs, was introduced as a useful way to control the release rate of drug and hydrophobic nature of HPMCP coating layer with a view for pharmaceutical application. The drug release and swelling were increased with increase in conductivity of aqueous HPMCP-NPs. On the other hand, particle size and polydispersity were decreased with increase in degree of neutralization.
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