免疫突触
细胞毒性T细胞
细胞生物学
细胞毒性
抗原
T细胞
生物
主要组织相容性复合体
抗原提呈细胞
化学
T细胞受体
免疫系统
免疫学
突触
神经科学
生物化学
体外
作者
Marco A. Purbhoo,Darrell J. Irvine,Johannes B. Huppa,Mark M. Davis
摘要
A notable feature of T lymphocyte recognition on other cell surfaces is the formation of a stable mature immunological synapse. Here we use a single-molecule labeling method to directly measure the number of ligands a cytotoxic T cell engages and track the consequences of that interaction by three-dimensional video microscopy. Like helper T cells, cytotoxic T cells were able to detect even a single foreign antigen but required about ten complexes of peptide-major histocompatibility complex (pMHC) to achieve full calcium increase and to form a mature synapse. Thus, cytotoxic T cells and helper T cells are more uniform in their antigen sensitivities than previously thought. Furthermore, only three pMHC complexes were required for killing, showing that stable synapse formation and complete signaling are not required for cytotoxicity.
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