化学
非共价相互作用
DNA
共价键
组合化学
复式(建筑)
配位复合体
纳米技术
金属
生物物理学
立体化学
生物化学
分子
氢键
有机化学
生物
材料科学
作者
Lucia Andrezálová,Zuzana Országhová
标识
DOI:10.1016/j.jinorgbio.2021.111624
摘要
Deoxyribonucleic acid plays a central role in crucial cellular processes, and many drugs exert their effects through binding to DNA. Since the discovery of cisplatin and its derivatives considerable attention of researchers has been focused on the development of novel anticancer metal-based drugs. Transition metal complexes, due to their great diversity in size and structure, have a big potential to modify DNA through diverse types of interactions, making them the prominent class of compounds for DNA targeted therapy. In this review we describe various binding modes of metal complexes to duplex DNA based on covalent and noncovalent interactions or combination of both. Specific examples of each binding mode as well as possible cytotoxic effects of metal complexes in tumor cells are presented.
科研通智能强力驱动
Strongly Powered by AbleSci AI