医学
背景(考古学)
髓母细胞瘤
放射治疗
重症监护医学
疾病
肿瘤科
介绍
内科学
作者
Kevin Beccaria,Laetitia Padovani,Yassine Bouchoucha,François Doz
出处
期刊:Current Opinion in Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2021-09-03
卷期号:33 (6): 615-620
被引量:2
标识
DOI:10.1097/cco.0000000000000788
摘要
The biological knowledge and the new biopathological classification of medulloblastoma subtypes have dramatically changed the therapeutic indications, taking into account not only age and staging but also biopathological risk criteria. This review covers the multidisciplinary approach including surgery, radiation oncology and medical treatments.The neurosurgical management of tumor-related hydrocephalus has been modified by the introduction of third ventriculostomy. The initial complete excision is no longer always the first choice, to preserve neurological function. The recent technical improvements of radiotherapy are also implemented to optimize outcome in terms of survival as well as quality of survival. The different medical treatments are adapted according to age and risk factors. The role of high-dose chemotherapy with autologous hematopoietic stem cell rescue has become larger in the high-risk situations.The rarity of the disease and the high-level of technicity of diagnosis, biopathological subtyping and treatments justifies the referral of these patients to highly specialized centers where all these techniques can be routinely applied, most often in the context of international prospective studies.
科研通智能强力驱动
Strongly Powered by AbleSci AI